Hi Jeff, thanks for responding. I have heard of the estradiol patch. I think it's an estrogen patch. No one mentioned it to me. All I know is that I have been losing weight and am already too skinny, and need to do something. I have looked at a bunch of forums on orchiectomy, and everyone says it's the best way to drop your testosterone fast. And it seems like everyone is glad they did it. I have all sorts of bad side affects from drugs. My doctor informed me that I might have to do some drug once we see how psa and another petscan show in a couple of months. I am 73 and very active. I bike everyday and usually hike about 3 times a week. I am having such inner turmoil with this. But I am a believer in Jesus and trusting in Jesus to bring me through. How are your side affects from orchiectomy?