Testosterone levels are rising after cessation of ADT

Here's my clinical history. In both cases, T rose to 300+ after three months and 400+ after six months after completing treatment.

In the first case, the PFS was roughly five years. In the 2nd, we are at 17 months, and PSA is stable at .03.

I am not naive enough to believe I am "cured...!" For high risk Advanced PCa I believe medical research has brought about ways to manage through imaging and treatment, but cure, no.

So, enjoy your T, continue to actively monitor through labs and consults. Think about and discuss with your medical team what clinical criteria would warrant going back on treatment and until then...

Kevin

I am stage 4a, grade 5, have had surgery, radiation and am currently 18 months into ADT therapy.
My PSA is undetectable still, my but testerone has jumped up to normal levels while still undergoing ADT injestions.
Wondering if I am now jumping into castration resistance phase.

I was on Lupron(adt) for 2 years... I also was on casadex for 2 years. I had radiation therapy first.
I did not have my prostate removed.
Gradually after 18 months of no ADT my testosterone levels returned to normal.
My psa has risen slowly to .09 but my oncologist says that is to be expected as testosterone levels return .
I have been assured that I have no biochemical recurrence at this time.
I am 4 years after my initial diagnosis . Hope this helps

I’m no expert but how can your T be approaching normal levels if you’ve been on ADT for 18 months? What does your Doc say?

I had the same result after 13 months of Lupron. I was also on darolutamide, which I've continued alone for subsequently 18 months. I assume the darolutamide is blocking utilization of T. My PSA is < 0.1.

Nubeqa (darolutamide) works in the presence of significant testosterone because it is an androgen receptor (AR) inhibitor, not a testosterone-reducing drug. It blocks testosterone's ability to stimulate prostate cancer cell growth by binding to the androgen receptor and preventing testosterone from attaching.

There are quite a few people in the Weekly ancan.org Advanced prostate cancer meetings that are only on Nubeqa. Most of them are older, and they really like the results since ADT can be difficult.

Can you send me a link to that weekly meeting. I too am doing Nubeqa mono therapy and would like to communicate with others doing the same. Stopped Lupron 6 months ago(had last 3 month shot 9 months ago).

Ancan.Org is the organization that does these weekly meetings. The next one is Tuesday the 23rd at 3pm pacific time. Get there 10 minutes early, That will make you first when they start talking to people. You should mention that I recommended you come to the meeting.

You can sign up at that website for information. They will send you a newsletter, Though it just came out today so you may not get this weeks newsletter.

You do have to have GoTo Meeting Installed on your computer, phone or tablet. It’s free just search for it. To get to the meeting with GoTo you can put in answercancer or 222583973.