Talk to your doctor. After a month on trial on off antibiotics it was eventually decided the reason of high fever- 103 was rifabutin. It was changed to IV three times a week of amikacin( I had a picc line) for three months and clofazimine every day and of course amoxicillin-every day. Then after my visit to NJH in January last year ethambutol three times a week was added to the regime. I was on the antibiotics for 23 months although my ID insisted 24 months but I had enough( very week and at the end abdominal pain every day) . I was MAC negative 5 months after started the treatment and continued the meds.dont be afraid of clofazimine. Besides being orangey ( looked quite nice) I tolerated it well.