Hi, I was diagnosed with MPN ET, November last year, complicated by having two mutations in the bone marrow Zak2 and Calr , I was on HU for few months but my haemaglobin kept dropping ( ending up getting three transfusions) , and was making no change to the platelets which were 650, I started on interferon injections 80 and now 130 weekly and Aranesp 300 every three weeks, my haemaglobin has now come up to 11.5 and platelets have dropped to 450. However the fatigue has become more chronic and difficult to cope with, a symptom of MPN and compounded by the two mutations. I am pacing myself and manage just pleased that the injections are at the moment working. I am older than many of you on this site, into my early 80's..hope the above information is of help