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Brinsupri (aka Brensocatib)

MAC & Bronchiectasis | Last Active: 6 hours ago | Replies (161)

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My BE seems to be that phenotype with high eosinophils. Nonetheless, until a DDP1 type drug comes out for us, I will pursue Brinsupri, which my doctor has recommended for me. My eosinophils are out of the normal range (600) but I've read others have numbers in the thousands and tens of thousands. They have come down considerably with allergy shots (used to be 2000). A daily allegra has also been very helpful in decreasing lung mucus, which has been draining from my sinuses.

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Replies to "My BE seems to be that phenotype with high eosinophils. Nonetheless, until a DDP1 type drug..."

WOW! 2000. I'm currently at 540. Singular was like a miracle drug for me until I started getting side effects-nausea. That was 20 years ago, long before I ever heard of BE I just read a study that inhaled corticosteroids (IC) helped those with eosinophil levels over 300. I understand the pitfalls of IC and Singular, but it leads me to ask, what is the worse of 2 evils. At this point, I am using an IC-which both my local and NJH doctor support. It's not ideal but I need it. My local pulmonologist wrote a script for 5 mg singular (half dose) to take at night but back in May, while still testing positive for MABC, my NJH doctor did not want me to take. The thing is, the Singular could eliminate my need for IC's. I'm tuning into the NJH NTM conference this weekend, so hopefully there will be some discussion on this. Last night, I listened to an NTM and BE NJH Research and Treatment Update Video dated 3/25/2022 sponsored by Insmed, and it was very interesting. I did not get the takeaway that I would benefit from the Brinsupri (during neutrophillic vs eosinophilic BE overview), but a lot of Brinsupri research has happened since 2022. Good luck and thank you for your reply. I have very mild rhinitis, but I'm going to start back up on Allegra-at least for now-see if it helps with my inflammation.