I contacted the FDA and Mayo Clinic. I’m telling you this is a bad medicine. It worked for the first two months, but I was covered in hives where my doctor told me to take Benadryl and constipation was unbelievably awful along with the hives and then this major teeth sensitivity. It takes six months for it to stop, but since then I’m extracting teeth the dentist is like the nerve endings have gone crazy and I’m getting root canals and extracting teeth I’ve never undergone such an issue in my life. It’s a bad bad drug not to mention. It’s ridiculously priced $2600. They’re out of their minds. I suggest everybody with migraines getting off of it and demanding Botox and have the Botox put over the optical nerves in your forehead on the bone between your eyebrows and on the crown of your head I went 6 1/2 years with what felt like my brain was on fire and putting the Botox on the crown of my head is what’s done the trick Good luck to your migraine suffers