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The lowest effective dose, how is it defined?
Polymyalgia Rheumatica (PMR) | Last Active: 6 days ago | Replies (141)Comment receiving replies
I will ask my doctor this week about splitting doses. He told me recently that it generally is not a good idea to take prednisone at night since it could have sleep side effects. The best time is the morning with breakfast.
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Splitting the dose does not mean splitting it 50/50. If the dose is split to control morning pain, the advice is to take a smaller dose in the late afternoon or early evening so as not to affect sleep. A later dose of even 1-2mg of the daily dose can be enough to control morning pain without affecting sleep.