After 1 week, Motegrity only worked for 3 days to different degrees. Day one -explosive diarrhea. Day 2 - normal bm! Day 3 - a few tiny stools. Now hasn't done anything for four days. Linzess was a similar experience. Back to playing mad scientist with OTC laxatives and stool softeners like miralax, CALM magnesium powder (worked one day). I know it's not a food, exercise, thyroid, hydration or pelvic floor issue. Why do our bodies reject everything we try to do to make our guts work normally!!! I wish more studies were done on those of us who have gotten to this point after having emergency childbirths that ripped into our rectal areas. My constipation problems began after that until now, 35 years later, I have it constantly.