I can't help but think there is some underlying condition that is making your bones fragile -- but what do I know! I am pleased with the outcome of my TKR, but a year later I am wondering why no one ever questioned doing it while I had a diagnosis of lymphedema in my leg. The diagnosis is in my chart, although no doctor has done more than look at my leg from across the room and check to see if it is pitting edema -- it's not. If it IS lymphedema, it makes the odds of infection and complications much higher, from what I've read, but no one ever brought it up. Thankfully I healed well. I have been reading up on the condition since no doctor so far seems interested, and what I read tells me I need treatment before it progresses, yet I was diagnosed 13 years ago, and it SHOULD have progressed by now if it is indeed lymphedema! It doesn't sound like any of the other look-alike diagnoses. I believe it would get attention if it suddenly started progressing, but then it would likely be too late, so I'd like to know what is really going on. I'm wondering why you had orthoscopic surgery at age 21. Do you have some sort of bone issue that just hasn't been recognized? Have you broken other bones easily? All of your doctors are probably focused on the knee replacement and maybe not looking for another condition, but from a quick internet search, I see it IS possible to have a bone condition that is particularly worse in one leg. Maybe start trying to find out WHY that leg breaks so easily.