Several thoughts (which I will preface with the statement that I am NOT a medical professional, just a poor unfortunate soul who's done a lot of research trying to figure out what's wrong with her):

1. If you have not already, have your Vitamin B12 checked; a sore, swollen, "beefy red" (boy was that weird to read in my office visit notes) and/or smooth tongue is characteristic of a B12 deficiency. The ridges/ripples/scallops/waves along the edges are typical signs of a swollen tongue, regardless of cause ( @johannahansen and @sbouchard77 ). Wearing a mouth guard, even if just for one night to assess if it's a teeth grinding problem, should "clear out" the ridges temporarily. Someone mentioned a "borderline low" B12 deficiency; I would advise him or her to check their actual lab results, as often there will be a level that, while not flagged low/deficient, comes with a disclaimer that some people within that level will still show symptoms of deficiency that should warrant considering treatment. Of particular importance to note is the frequent mention of proton-pump inhibitors (PPIs) including Pantoprazole/Protonix and Omeprazole/Prilosec and to a slightly lesser extent H2 blockers including Famotidine/Pepcid and Ranitidine/Zantac can prevent absorption of vitamins (B12 in particular) with long-term use and are associated with increased risk of B12 deficiency.

2. My immediate reaction when reading a lot of these posts was "Mastocytosis and/or Mast Cell Activation Disorder." These cause allergic reactions, often unpredictable and from varying and often changing triggers, that can be as severe as an anaphylactic reaction like we normally associate with bee stings (lip/tongue/throat swelling, hives, itching, etc.). These are most frequently treated by allergists/immunologists (like most of you were) and are typically treated with a regimen of the drugs you received: H1 antihistamines (Claritin/Loratidine, Zyrtec, etc.); H2 antihistamines (Famotidine/Pepcid, Ranitidine/Zantac, etc.); Leukotriene Inhibitors (Singulair/Montelukast, etc.) and when GERD continues to be problematic, a PPI (Omeprazole/Prilosec, Pantoprazole/Protonix, etc.). Mastocytosis is fairly well-known, so I suspect you would have likely been tested for that by any competent allergist/immunologist (usually involves a consistently elevated tryptase level), but Mast Cell Activation Syndromes are a more "recent" discovery/definition and may not be as widely known. Check out https://tmsforacure.org/overview/ for a wealth of information on both mastocytosis and mast cell activation syndromes.

3. In terms of general allergies, if you have not already, ask about having your Total IgE - if your level is normal, it's unlikely (although not impossible) that allergies are playing a role; learn more at https://labtestsonline.org/tests/total-ige. You can also have Allergen-specific IgE levels tested if there's something you specifically suspect is causing your symptoms (ex., the question about dog dander or food allergies); see https://labtestsonline.org/tests/allergy-blood-testing.

4. Finally, as more of a long-shot, I wanted to mention the recent discovery of meat allergies resulting from tick bites. @jerryd 's mention of moving to a lakefront location with lots of open fields reminded me of an article I read recently about it. If I recall correctly, it's more frequently associated with men and there's a delayed reaction between ingestion and symptoms. OH, I just found this article -- Jerry, tell me this doesn't sound like you?: "If you start to have trouble breathing in the middle of the night, you probably are not going to blame the hamburger you had for dinner." https://labtestsonline.org/news/meat-allergy-tick-bites-most-common-cause-anaphylaxis-clinic

Good luck folks! Hope you find some relief/answers.