Severe itching with PV

After 2 years of very little itching on baby aspirin, I was, for a variety of reasons, switched to Eliquis. I now have mild itching during the day but starting at 10pm it becomes worse until midnight, when it’s intolerable. Zantac and Zyrtec taken together work sometimes but not reliably. Beta Alanine taken with both, helps a little but the severity is sometimes so intolerable that I am pacing all night or taking multiple showers and applying lots of lotion. Have any of you experienced this late night problem ( which may be regulated by cortisol levels) and what have you found actually works? I would be so grateful for your suggestions. Living without sleep is not working. Benedryl is not a long term option.