Hi, I have Triple Negative ET. I am only 42 years old and my symptoms started about 6 years ago. I am on Besremi and have been for around 8 months now. I was on HU for about a month or two but notice that my symptoms of ET were actually getting worse while on it. Also, was having other side effects from the HU. My Hematologists/Oncologist decided that the next step was Besremi. I had some side effects, but they started me off slow with the dosage (started 50mcg every two weeks, now I am at 300mcg every two week and will be upped probably next week). I do get nausea from time to time. I already suffer from anxiety and unfortunately we noticed that Besremi does affect my anxiety levels by making them worse, but I just upped the dose on the anxiety medication to help with this. I love Besremi. To me it is a miracle. I was in a terrible spot when the doctors finally figured it out. I wish you the best of luck with it and I pray that it helps you like it has helped me.