I only have mild asthma, but started Dupixent with loading dose for another condition 2 weeks ago. I'd had a sample dose 5 weeks before. They ship them to me and I self inject. Was tired first evening, but ok and no issues. I do get red area at injection site for 24 hours. It's helping. I have only mild asthma that is coughing, not wheezing, and it rarely causes issues for me.
I'm not sure if that's what you're looking for.

Mostly, I'm worried about side effects, and you sound as though you haven't had major side effects. That's reassuring. Thank you!

I’ve been on Dupixant for a year and half. Not noticed side effects. It allowed me to wean off the nebulizer. I took about 6 months to notice the change. I am and have been asthmatic since birth. I currently use strongest dose and self inject twice a month.

I have been asthmatic since age 4 (now 62 yo). I was on Xolair - the very first biologic, for 15 years until it stopped working. I was changed to Tespire - to which I had bad reactions and wound up worse and hospitalized (it only worked for 6 weeks). I have been on Dupixant (about 2 years) which has made a terrific difference in my life. Yes, it took a while for it to start working, but it has allowed me to decrease prednisone - as I am steroid dependent for my asthma. I self inject every 2 weeks. I do get redness at the injection site and used to get tired for the first 1-2 days. I do notice some increased asthma about 2-3 days prior to the next injection - but that goes away a day after the Dupixant. I have had fewer major asthma attacks which require hospitalization. However, I am blessed to have a great supportive family, and a wonderful pulmonologist.

Something you may consider adding it Magnesium Glycinate. Magnesium is good for asthma/respiratory problems and glycinate is the best form which is absorbed by the body. Remain hydrated - especially for bronchiectasis - as medically permitted. (Many congestive heart failure patients need to limit their fluid to 1.5 liters per day.) If necessary, ask your provider about a vibration vest, to help with loosening the secretions when it gets very bad. For bronchiectasis, it is also helpful to lower your head of bed (with legs higher), as the gravity helps the secretions to get out of the body. Good luck.

I have emphysema & brochiectasis. I was on Fasenra successfully four years until my pulmonologist wanted me to try Dupixent. In those four years my eosinophils got to zero but I still developed those lung diseases (I am newly diagnosed). Immediately after my first Dupixent dose I had severe head & neck pain. I suffer from these anyway due to cervical stenosis & I struggle with inflammation so believe Dupixent caused the severe inflammation. I stopped Dupixent at that time. My daughter, who has my same underlying genetic lung condition, is on dose five of Dupixent (after four years on Xolair). She has done very well, is prone to severe viral infections, and she will continue ad the Dr says Dupixent is her #1 biologic for people like her who struggle with infections.

Thank you pacathy - yes, you are right - if there is reflux head of bed down could cause more reflux or aspiration. I was thinking if only the person had bronchiectasis (without reflux). If one cannot tolerate or head of bed lowered is not good for that person - a vibration vest may be a good solution to wear during daytime, to help with the secretions.

I have tried all FDA approved biologics for asthma. I highly recommend you do some extensive research on Dupixent before you agree to try it look at NIH research and clinical studies & some of the major research hospital such as Cleveland and Mayo. If you dig deep, you will find that there are “rare” cases of seronegative arthritis (RA), squamous cell carcinoma, thyroid cancer, etc. associated with Dupixent. Unfortunately, I have had all 3 of these rare occurrences, and have undergone more than 18 surgeries since 2020 to include thyroid cancer surgery, squamous cell carcinoma with MOHs, and double total knee replacement due to seronegative rheumatoid arthritis in the beginning and now I have seropositive. I was recently diagnosed with broncheatasis with aspergillus fumigatus and pseudomonas aeruginosa colonized in my lower respiratory tract due to suppressed immune system which is exactly what biologics do. In my opinion, Dupixent is by far the biologic with the most horrific side effects. I was ignorant and trusting of my pulmonologist at the time, but I have found they do not do the research themselves and rely on FDA, pharmaceutical companies and pharm sales for information. Best of luck.