Any experiences with Provenge immunotherapy for prostate cancer?

Following. No PSMA Pet Scan? Specifically, a PSMA PET SCAN not just a regular PET Scan.

I just completed paperwork for the treatment of Provenge. Paperwork was sent to my insurance for approval. My question is, has anyone received this treatment. My doctor said it should help to gain one or two additional years. What was your experience.
Best wishes for all of us to have best lives.

I know a few people who have had Provenge. It’s good to have it when your PSA is still low. It is hoped that will give extra time. Actual results are a little hard to estimate.

In the IMPACT clinical trial, Provenge extended the median overall survival of men with metastatic castration-resistant prostate cancer (mCRPC) by 4.1 months compared to placebo. The median survival in the Provenge group was 25.8 months versus 21.7 months in the control group.

Had a recent conversation with a client about our PC and he had the Provenge 12 years ago and had a 1900 PSA.
Still on Xtandi, about 70 now and undetectable. Amazing!

Thank you for that information

Thank you for your input.

We are considering Prevenge because Dad doesn't think he can handle the pluvicto treatments. Can you tell me how yours is doing? We are Memorial Regional and unsure if the Radiology Oncology is exagerating or over imploding microscopic cancer ........ this is all over Dad's bones as well. However, prostate cancer is slow and we are banking on the slowness of the progression.

There is a major difference between Pluvicto and Proveng.

Pluvicto is designed to attack multiple metastasis and reduce them in some cases dramatically.

Proveng is really not designed for that kind of treatment. It can help fight metastasis, but not do the Significant damage To cancer Mets that Pluvicto can do.

Talk to your doctor about this, I think you will find that You can reduce significant cancer mets with Pluvicto, something Proveng is not as helpful for.

This link discusses how PROVENGE is specifically indicated for the treatment of asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer.
https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/questions-and-answers-provenge.
Somebody receiving Pluvicto cannot get Provenge infusions to do the same thing. While both are advanced treatments for metastatic prostate cancer, they are fundamentally different types of therapy that work through completely separate mechanisms.

Ive started this treatment. I was wondering how your treatment proceeded and your results. Ant side effects during treatmentThank you

I know a couple of people that have had it, results are long-term. None of them reported serious problems, but side effects are possible. You are supposed to get Provenge when your PSA is very low.

Here is some detailed information about side effects from one of the PCRI conferences.

PROVENGE is made from your own immune cells, which are collected during a process called leukapheresis. The cells are processed, returned, and then infused back into the patient through an IV (intravenous) infusion approximately three days later. This process is completed in three cycles, about two weeks apart. Each infusion takes approximately one hour and requires 30 minutes of post infusion monitoring.
•Provenge infusion can cause serious reactions. Tell your doctor right away if you:
• Have signs of a heart attack or lung problems, such as trouble breathing, chest pains, racing or irregular heartbeats, high or low blood pressure, dizziness, fainting, nausea, or vomiting.
• Have signs of a stroke, such as numbness or weakness on one side of the body, decreased vision in one eye, or difficulty speaking.
• Develop symptoms of thrombosis which may include, pain and or swelling of an arm or leg with warmth over the affected area discoloration of an arm or leg, shortness of breath, chest pain that worsens on deep breathing
• Have signs of infection such as fever over 100°F, redness or pain at the infusion or collection sites.
Tell your doctor about any side effect that concerns you or does not go away. For more information, talk with your doctor.