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Any experiences with Provenge immunotherapy for prostate cancer?

Posted by sm0534 @sm0534, Nov 16, 2023

I have advanced stage of prostate cancer which has spread to other parts of my body like neck and chest. Oncologist recommended Provenge immunotherapy and I followed up with it.
Unfortunately after 6 months, PET scan shows new cells forming in those areas. Apparently Provenge hasn't worked and money has been wasted on this very expensive drug.
Does anybody have experience with Provenge and what would be my next steps. I have been taking Lupron and I tried XTANDI for which I had severe side effects

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

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chippydoo | @chippydoo | Feb 17 9:20am
In reply to @lorenze76 "In 2023 his psa was 2 and in 2024 it was 154. He has had multiple..." + (show)
Profile picture for lorenze76 @lorenze76

In 2023 his psa was 2 and in 2024 it was 154. He has had multiple scans but I think I’m going to ask them to do another one soon. The dr at Md Anderson said pet scans really don’t show prostate cancer so he prefers ct scans. Tell me about the belt or better yet a link maybe. If it will help we will get whatever he needs. Oh and we do know his is all over his bones .

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Following. No PSMA Pet Scan? Specifically, a PSMA PET SCAN not just a regular PET Scan.

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Colleen Young, Connect Director | @colleenyoung | Mar 1 12:56pm
In reply to @lorenze76 "Has anyone had experience with Provenge treatment? Dad age 75 diagnosed April 2023 with mestatic prostate..." + (show)
Profile picture for lorenze76 @lorenze76

Has anyone had experience with Provenge treatment? Dad age 75 diagnosed April 2023 with mestatic prostate cancer - wide spread to bones and psa was 154. He has been on xtandi and orgovyx since being diagnosed and psa has dropped to 3.6. Just recently it rose to 4.4 after 4 months so they are suggesting Provenge and we wanted other opinions. Has anyone else’s psa rose a point but doctors just continued monitoring or did they immediately jump to next plan?

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@lorenze76, I moved your question about Provenge immunotherapy treatment for advanced prostate cancer to this existing discussion where @sm0534 asked similar questions.

See previous posts here:
- Any experiences with Provenge immunotherapy for prostate cancer?https://connect.mayoclinic.org/discussion/provenge-effectiveness/

Did your father and his oncologist decide to start Provenge? How is he doing?

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newby82 | @newby82 | Aug 28 3:12am
In reply to @lorenze76 "In 2023 his psa was 2 and in 2024 it was 154. He has had multiple..." + (show)
Profile picture for lorenze76 @lorenze76

In 2023 his psa was 2 and in 2024 it was 154. He has had multiple scans but I think I’m going to ask them to do another one soon. The dr at Md Anderson said pet scans really don’t show prostate cancer so he prefers ct scans. Tell me about the belt or better yet a link maybe. If it will help we will get whatever he needs. Oh and we do know his is all over his bones .

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We are considering Prevenge because Dad doesn't think he can handle the pluvicto treatments. Can you tell me how yours is doing? We are Memorial Regional and unsure if the Radiology Oncology is exagerating or over imploding microscopic cancer ........ this is all over Dad's bones as well. However, prostate cancer is slow and we are banking on the slowness of the progression.

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jeff Marchi | @jeffmarc | Aug 28 10:34am
In reply to @newby82 "We are considering Prevenge because Dad doesn't think he can handle the pluvicto treatments. Can you..." + (show)
Profile picture for newby82 @newby82

We are considering Prevenge because Dad doesn't think he can handle the pluvicto treatments. Can you tell me how yours is doing? We are Memorial Regional and unsure if the Radiology Oncology is exagerating or over imploding microscopic cancer ........ this is all over Dad's bones as well. However, prostate cancer is slow and we are banking on the slowness of the progression.

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There is a major difference between Pluvicto and Proveng.

Pluvicto is designed to attack multiple metastasis and reduce them in some cases dramatically.

Proveng is really not designed for that kind of treatment. It can help fight metastasis, but not do the Significant damage To cancer Mets that Pluvicto can do.

Talk to your doctor about this, I think you will find that You can reduce significant cancer mets with Pluvicto, something Proveng is not as helpful for.

This link discusses how PROVENGE is specifically indicated for the treatment of asymptomatic or minimally symptomatic metastatic castrate resistant (hormone refractory) prostate cancer.
https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/questions-and-answers-provenge#:~:text=PROVENGE%20(sipuleucel%2DT)%20is,called%20PAP%2DGM%2DCSF.
Somebody receiving Pluvicto cannot get Provenge infusions to do the same thing. While both are advanced treatments for metastatic prostate cancer, they are fundamentally different types of therapy that work through completely separate mechanisms.

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