← Return to Drug-induced PN due to tirzepatide

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Drug-induced PN due to tirzepatide

Neuropathy | Last Active: Oct 17 12:36pm | Replies (14)

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Profile picture for moddydammy @moddydammy

I am currently experiencing this as well. It's awful! I now have drop foot in both feet. Trying to help has been beyond frustrating. Any advice would so be appreciated. Everything is getting worse. I stopped zepbound six weeks ago.

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Replies to "I am currently experiencing this as well. It's awful! I now have drop foot in both..."

Hi @moddydammy, Welcome to Connect. Sorry to hear that you have drug induced neuropathy and now have developed drop foot in both feet. The Foundation for Peripheral Neuropathy has a list of different treatments if you haven't already seen them - https://www.foundationforpn.org/treatments/. Others have mentioned using orthotics to help with drop foot. Have you discussed it with your doctor or foot specialist to see if they may have any suggestions?

You have my complete sympathy, both for the symptoms and the challenges finding help for something that is as rare as non-oncological DIPN -- in my experience, no one really knows what to do about it. Although to be fair, pretty much no one knows what to do about oncological DIPN, either. I've got a running weekly JAMA search on DIPN, and it keeps coming up with essentially nothing of any use, arguing that it's even an unpromising study area. (A search for tirzepatide or semaglutide, however, produces dozens of results every week. None of which, of course, mention DIPN.) So completely agree with @johnbishop : about the only thing you can get from a neurologist is advice on how to keep it from getting worse (avoid vitamin B6, for example). Beyond that, this is a great forum for finding practical things you can do to just cope, like, for example, orthotics or shoes or socks.

Welcome to a very special club!