@vi30295 re how long for carbidopa/levadopa. I’m considered early Parkinsonism, and for me after about two weeks I noticed tremor improvement, and after three weeks I noticed I was sleeping better which I was not expecting. I have no idea if that improvement is related to the drug , need others to weigh in. Two of the family members I have cared for experienced “sundowning”, so I know how exhausted you must be. Search for sundowners both within and outside of this Parkinsons topic. My experience is dated back to 2009, but I was lucky in that the trazodone with melatonin worked for us. Maybe something newer has come out. I am so sorry your family is going through this.