Fluorouracil treatment

Posted by bill60 @bill60, Feb 2 7:49am

I went to my dermatologist yesterday. I have sun damage on my face, legs and arms. I am have bumps on my leg, and it is itchy. He suggested I try the Fluorouracil treatment. He did tell me it will get red and may become uncomfortable. When I picked up the prescription I read the possible side affects. This scares me. Can someone who has gone through the treatments help me with some advise. Thank you.

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I had to use this for 3 weeks 2x a day on precancerous spots on my scalp. I didn’t notice any side effects except my hair is thin in those areas.

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Profile picture for 6506heege @6506heege

Any comments on using flour or ail on the scalp to remove possible precancerous lesions?

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I will start the same treatment on my scalp, and would appreciate any comments from experienced users.

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Profile picture for davef @davef

It’s not really painful unless you get it into a fold of skin, so avoid the inside of the elbows, back of the knees, and be careful on your neck.
Wear tight fitting sleeves and avoid the pool.
The redness goes away in a few days.

The latest treatment has Florouracil combined w Calcapotriene. I just started that this week. Really does work better than Florouracil on its own.

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Looking into using the combo.... do you apply separately or is it premixed?

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They are separate. Apply one, then the other. Fantastic results but don’t get it in the folds of your skin!!!

Best idea*. is to get some sun sleeves for your forearms. Apply the combo, put the sleeves on. The compression fit will keep the skin from touching other areas of skin. You’ll thank me later.

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Well, I was one of the few unfortunate ones who had a near-deadly reaction to it, called 5-FU toxicity. Thanks to a Mayo Genetic Oncologist quite a few years back, there's now an antidote, but I warn everyone using it to just pay close attention to any sudden severe symptoms. It actually destroyed my liver and I'm now on the transplant list. Mine is a rare case, though. My husband and two neighbors have used it and had very successful results. Mine is apparently a genetic issue.

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I had a horrible reaction to it, my throat started closing up. Because of the reaction I have to use Imiquimod on any precancerous areas. That being said my dermatologist didn’t tell me to not use a lot and I thought I had to use most of the packet on the spot. On my 11th night I was sitting and watching television and all of a sudden I felt water on my face and here suddenly the area blistered and broke and the fluid was running down my face. This happened about 4 years ago and the mark is totally gone. I actually just started using again last night for another spot but I learned from my mistake and only use a drop on the area. I’m scared to death to use much more than that after my last experience. I also have Grover’s Disease and I don’t wish that on anyone.

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Profile picture for toucanmom @toucanmom

Well, I was one of the few unfortunate ones who had a near-deadly reaction to it, called 5-FU toxicity. Thanks to a Mayo Genetic Oncologist quite a few years back, there's now an antidote, but I warn everyone using it to just pay close attention to any sudden severe symptoms. It actually destroyed my liver and I'm now on the transplant list. Mine is a rare case, though. My husband and two neighbors have used it and had very successful results. Mine is apparently a genetic issue.

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I was told you can not apply to more than 10% of your skin at any one session.
Sorry to hear about your reaction, but it is important to get the information and as always consult your physician.

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Profile picture for jan2783 @jan2783

I had a horrible reaction to it, my throat started closing up. Because of the reaction I have to use Imiquimod on any precancerous areas. That being said my dermatologist didn’t tell me to not use a lot and I thought I had to use most of the packet on the spot. On my 11th night I was sitting and watching television and all of a sudden I felt water on my face and here suddenly the area blistered and broke and the fluid was running down my face. This happened about 4 years ago and the mark is totally gone. I actually just started using again last night for another spot but I learned from my mistake and only use a drop on the area. I’m scared to death to use much more than that after my last experience. I also have Grover’s Disease and I don’t wish that on anyone.

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Discuss with your dermatologist BLUE LIGHT treatment as an excellent alternative to 5FU

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Profile picture for Ginger, Volunteer Mentor @gingerw

@bill60 Welcome to Mayo Clinic Connect! Topical treatments can have different effects on us. @davef gave you some great tips!

As fluorouracil starts to work, you might get reaction in an area where you didn't apply it. Not to worry, it just means the medication is tracking down the bad stuff and fighting it. I remember the first time I had that happen to me, rushing back to the dermatologist and their amused response to my concern! Be careful about using any lotions while you do this, as it will negate some of the medication action if you use anything in the same area. After the redness and scabbing starts to go away, it's okay to go back to a light lotion. Stay out of the sun! Cover up! I like to think that when I see the redness appearing, it means things are working and I am taking care of myself. Oftentimes that redness appears on my face, and oh well! just ignore the stares from people.
Ginger

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@gingerw I'm getting ready to start the cream. I'm worried about my dog licking my face. She is a 10 pound dog and sleeps in my bed. Can I cover my nose with a bandage? Will the cream get onto the bedding pillow? How do I protect her? Not sure what to do. I'm really scared I might make a mistake.

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I'm getting ready to start the fluorouracil cream. I'm worried about my dog licking my face. She is a 10 pound dog and sleeps in my bed. Can I cover my nose with a bandage? Will the cream get onto the bedding pillow? How do I protect her? Not sure what to do. I'm really scared I might make a mistake.

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