I had a horrible reaction to it, my throat started closing up. Because of the reaction I have to use Imiquimod on any precancerous areas. That being said my dermatologist didn’t tell me to not use a lot and I thought I had to use most of the packet on the spot. On my 11th night I was sitting and watching television and all of a sudden I felt water on my face and here suddenly the area blistered and broke and the fluid was running down my face. This happened about 4 years ago and the mark is totally gone. I actually just started using again last night for another spot but I learned from my mistake and only use a drop on the area. I’m scared to death to use much more than that after my last experience. I also have Grover’s Disease and I don’t wish that on anyone.