What is the recommended treatment after 6 Pluvicto doses?

It sounds like the current Pluvicto infusion protocol is different than the one that was used during the original clinical trial you were in. What you had last Tuesday is exactly the same protocol as my husband has had at Mayo Rochester since January 2024. He is just infused with the Pluvicto, no other medications before or during the infusion, and told afterward to use the Zofran and/or Miralax as needed if those side effects occur. Your fatigue and slight nausea and touchy stomach are the same very common side effects my husband had after his first Pluvicto infusion. They did lessen with each subsequent infusion. So hang in there!

Very helpful discussion, thank youth all. I am 3.9 years in/w APC (Advanced Prostate cancer), PSA is rising, but I've learned over time PSA is a good indicator that moves occasionally and carries lots of emotional baggage from my big one, 118, 3.11 years ago. I enter the Pluvicto orbit next week with first oncologist session/discussion about it. Oncology nurse called yesterday and explained/outlined the entire process.

So helpful.

Please keep us posted and feel free to ask any questions you have as you progress through the Pluvicto infusions. We are all happy to share our experiences and what we have learned going through the treatments. And good luck to you!

Odd, my 6 Pluvicto treatments were administered without additional medication or ice chips. Is your dose the same as the first 6 treatments?
My PSA entered Pluvicto at 10.8 and ended at 0.15. Waiting for latest PSA and PET to be shared next week. Side effects were minimal until #6 then slight nausea.
Following with interest for a follow up possibilities.

I was diagnosed with stage 4 prostate cancer in 2018. I will be starting Pluvicto in October. My wife and I are in our 70s. We have a small house and spend a lot of time together. I would like to know if you are married or have a life partner or anyone sharing a home with you. If so, how did you deal with separation time after your treatments? We are trying to work out the details now and I would appreciate any advice. My Radiation Oncologist says we should not share space for 7 - 10 days after each treatment. I welcome any kind of advice from anyone who has experienced Pluvicto. I feel like I need all the help I can get. Thank you.

Don’t get too worried about radioactivity warnings. Don’t overdo like some men do. No need to buy a Geiger counter or totally isolate yourself for days!

Limit close contact (less than 3 feet) with household contacts for two days after each dose.

Sleep in a separate bedroom from other household members for three days.

The good news is that most of the radiation is eliminated from the body relatively quickly. Over half the radiation will be gone within two days, and over 99% will be gone within about 14 days.

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people. If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.

My husband had his Pluvicto treatments in 2024 at Mayo Rochester. We got thorough recommendations and advice from Mayo radiation oncology, nuclear medicine, and theranostic providers. Their advice for keeping your distance after each infusion was not even close to the 7-10 days that your radiation oncologist has told you. That seems very excessive and unnecessary when compared to the advice we got and to what many others on this forum have reported getting. If you would like to see the less stringent recommendations we and others have gotten, just say so and someone can post them here for you.