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Reclast: Poor Result...Next steps

Osteoporosis & Bone Health | Last Active: Sep 26, 2025 | Replies (35)

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Profile picture for pauladiamante @pauladiamante

Yes CTX is the breakdown molecule.Osteoclasts are responsible for the breakdown.
P1NP is the evidence of building Osteoblasts build.
Since bones are a living organ system they should be continuously "remodeling". Responding to the environment. Turning over new bone. Breaking down the old. While making new.. just like your skin does every day. That's the problem with prolia and the bisphosphonates. They stop the breakdown. So the CTX is very low. But it's old brittle dead bone piling up. A product that does BOTH build new bone AND slow the breakdown are the newest on the market. And are titrated by watching this wax and wane.

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Replies to "Yes CTX is the breakdown molecule.Osteoclasts are responsible for the breakdown. P1NP is the evidence of..."

Since gently keeps tabs on both markers during and off therapy, I'm pretty sure she knows what she's saying - if anything, her wording might just invite more interpretations than she intended haha.

“ A product that does BOTH build new bone AND slow the breakdown are the newest on the market. And are titrated by watching this wax and wane.”: That's interesting. Would you mind sharing the source? I'd like to read up on it. Thanks

Could you share more details on this new product? “ A product that does BOTH build new bone AND slow the breakdown are the newest on the market. And are titrated by watching this wax and wane.” I’m really interested in learning this product! I have pretty severe osteoporosis and really need to improve my bones badly.

Thanks!