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DiscussionDeciding what to do when providers have such different protocols?
Prostate Cancer | Last Active: Aug 19 12:04pm | Replies (13)Comment receiving replies
Replies to "I had a prostatectomy in July 2008 w/ divinci robot. Checking PSA every 6 months, last..."
That is a big jump. I would want to be tested in three months and not wait six months. The doubling rate is the most critical number, It really is necessary to see what the next number is to know what the doubling rate actually is.
If you don’t get salvage radiation soon after you hit .2 it can cause your cancer to be more aggressive. There’s a lot of opinions about this, But ASCO is pretty definitive about this, and they set the guidelines.
Here’s what they have to say about Having your PSA rise too much
From Ascopubs about what PSA to do salvage radiation.
≤0.2 ng/mL:
Starting at this level maximizes disease control and long-term survival. Patients treated at PSA < 0.2 ng/mL achieve higher rates of undetectable post-SRT PSA (56-70%) and improved 5-year progression-free survival (62.7-75%).
Delaying SRT beyond PSA ≥0.25 ng/mL increases mortality risk by ~50%.
0.2–0.5 ng/mL: Still effective, particularly for patients with low-risk features (e.g., Gleason ≤7, slow PSA doubling time). The Journal of Clinical Oncology recommends SRT before PSA exceeds 0.25 ng/mL to preserve curative potential.
0.5–1.0 ng/mL:
Salvage radiation remains beneficial but may require combining with androgen deprivation therapy (ADT) for higher-risk cases.
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Yes, it is a concern but PSAs can sometimes jump around. Your next tests should be 3 months apart and you need to look for a consistent rise - and the velocity of it - in order to determine if salvage therapy is warranted.