Keytruda/Lenvima - positive results?

I start Lenvima Aug 5,I am currently on keytruda stand alone. Dx endometrial ca with mets serous Dec 2025.Doing well had 3 ct scans tx is working early response when Doing chemo completed May12,2025. Problem is I don't it have the biomarkers for keytruda that's why oncologist is adding Lenvima 20mg. I am. very nervous about the dosage n side effects.

Sorry to hear what you are going through! The misdiagnosis must shake your trust a bit in the medical field. I've done Paxitaxel, Keytruda, and Carbo platin for 6 cycles at 6 hours a shot every 3 weeks - 18 weeks. I am also wiped out. CT scan indicates cancer growth, so not sure how much it helped. They want to to just do the Keytruda by itself and referred me to palliative care. I'll let you know how I do on Keytruda alone as far as side effects. I think I am out of Western Medicine options. I read Radical Remission, listen to William Li on You Tube about diet, and also read about Thomas Seyfried and his theory that cancer is, at least in part, a metabolic disease. I have changed my diet to eleminate sweets and carbs but the cancer is still gaining on me. I'm not giving up though, and will do what I can to keep fighting it. I may try Seyfrieds Press Pulse program. Your comment encourages me to seek out a second opinion. Thank you for sharing your difficult journey.

Hello, Thank you . I just posted on the other site. I'm on 12mg and keytruda, just finishing 1st cycle. Side effects are very dry mouth, extreme hoarseness and absolute fatigue (latter may be left over from the hormonal therapy we tried for 3 moths based on a misdiagnosis of endometroid vs hi grade serous in 2021)

Sorry to hear what you are going through! The misdiagnosis must shake your trust a bit in the medical field. I've done Paxitaxel, Keytruda, and Carbo platin for 6 cycles at 6 hours a shot every 3 weeks - 18 weeks. I am also wiped out. CT scan indicates cancer growth, so not sure how much it helped. They want to to just do the Keytruda by itself and referred me to palliative care. I'll let you know how I do on Keytruda alone as far as side effects. I think I am out of Western Medicine options. I read Radical Remission, listen to William Li on You Tube about diet, and also read about Thomas Seyfried and his theory that cancer is, at least in part, a metabolic disease. I have changed my diet to eleminate sweets and carbs but the cancer is still gaining on me. I'm not giving up though, and will do what I can to keep fighting it. I may try Seyfrieds Press Pulse program. Your comment encourages me to seek out a second opinion. Thank you for sharing your difficult journey.

Sorry to hear what you are going through! The misdiagnosis must shake your trust a bit in the medical field. I've done Paxitaxel, Keytruda, and Carbo platin for 6 cycles at 6 hours a shot every 3 weeks - 18 weeks. I am also wiped out. CT scan indicates cancer growth, so not sure how much it helped. They want to to just do the Keytruda by itself and referred me to palliative care. I'll let you know how I do on Keytruda alone as far as side effects. I think I am out of Western Medicine options. I read Radical Remission, listen to William Li on You Tube about diet, and also read about Thomas Seyfried and his theory that cancer is, at least in part, a metabolic disease. I have changed my diet to eleminate sweets and carbs but the cancer is still gaining on me. I'm not giving up though, and will do what I can to keep fighting it. I may try Seyfrieds Press Pulse program. Your comment encourages me to seek out a second opinion. Thank you for sharing your difficult journey.

I'm not a doctor, but I really think you should do everything you can to try Enhertu (I recall that you're HER2+, correct?). If your doctor can't get you on it, you should try a different doctor. If you are in the US, you are absolutely eligible for it now, having failed platinum based chemotherapy.

IMO it's crazy for them to keep you on Keytruda. If it didn't work together with carbo/taxol, it's not going to work alone. It's things like this that make me wonder if doctors have a financial incentive to order Keytruda, which makes huge amounts of money for Merck per dose.

There have been some not-so-happy campers on Enhertu on this forum lately, but other people have had pretty good experiences. It would be a shame not to try it.

Had to go off Carboplatin because I had allergic reaction to it. Have any of you experienced hearing loss due to Carboplatin?

Hello
Thanks so much for this! I gave me a little hope when I was feeling pretty discouraged.
My Dr. tried to get me on Enhertu at beginning and it was turned down by insurance. I have Clear Cell Carcinoma which is rare, so that said it wasn't standard treatment. She then tried to get me on it as a "compassionate" case but no luck. I have a conference this Tuesday. She will at least get me on a similar drug. She canceled this weeks chomo. Not sure whether she finally looked at my test results, or if in response to me questioning.