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Hello and thank you for your response and the link to the Mayo Clinic publication. You asked for context and what I’ve been told by my doctor. Here is what I can tell you:
I’m an 82 year old Caucasian woman. My PCP ordered extensive bloodwork since I’ve complained of what appears to be peripheral neuropathy. I’m prediabetic with an A1C of 6.2. I also have a tingling feeling on my lips and other oral problems for which I’ll be seeing both an ENT and a rheumatologist.
The lab report reads: “There is an M spike in the gamma region measuring 0.61 G per DL. SIFE: There is a corresponding monoclonal IGG KAPPA. “
It further says: KAPPA LIGHT CHN, FR, S of 28.5 flagged as being high.
LAMBDA LIGHT CH, FR, S flagged as normal at 12.5
My PCP sent me to a hematologist who explained that I have MGUS that has a small likelihood of developing into multiple myeloma. Another blood draw was done which is one month after the one ordered by my PCP). Apparently this was done to determine the rate/rapidity of progression of the disease. My next visit to the hematologist is scheduled in three months.
I have no family history of multiple myeloma but both of my parents and my only sibling have died of other cancers.
I hope that you and/or others on Mayo Connect can Offer their comments and insights on my situation.
Thank you.

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Replies to "Hello and thank you for your response and the link to the Mayo Clinic publication. You..."

@googi
Thanks for the context. As you have been told and have read, the likelihood of your MGUS advancing to Multiple Myeloma is low.
I would rather not have it, but since I do, it has meant that I get some really excellent healthcare. As others can attest, your hematologist will initually schedule appointments more frequently in order to see how stable your lab results stay. You may also get CT or PET scans to ensure you don’t have bone lesions, indicative of progression to Multiple Myeloma.
Coexisting conditions such as diabetes, age and other indicators of overall general health are considerations, so your hematologist is the best resource for information. Do ask for a consultation if you find that you still have unanswered questions.
Lots of our MGUS members have experienced neuropathy. I started feeling numbness in my feet a couple of years before I was diagnosed with MGUS which in retrospect makes me think I’ve had MGUS a lot longer than my initial diagnosis 4 years ago. There are some medications that may be helpful to you. Ask for a referral to a neurologist if that is not yet happened.
Our members have shared information about diet and supplements that they have found helpful. I am experimenting with 2000mg daily of Curcumin after talking with my PCP doctor, pharmacist, hematologist and other members. My numbers went down but then went up slightly which I attribute to having major surgery. We’ll see if they stabilize when I go back next month.
The link below may be helpful to you about understanding lab results.
I’m really glad you found us.
https://www.myelomacentral.com/livingwithmm/multiple-myeloma-treatment-monitoring/understanding-multiple-myeloma-lab-test-results