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PMR Diet: Foods to eat and avoid
Polymyalgia Rheumatica (PMR) | Last Active: Aug 17 4:40pm | Replies (133)Comment receiving replies
Melatonin is anti-inflammatory. The cytokine release is due to the lowered amount of cortisol overnight I believe. I take 2mg of Melatonin each night to help with sleep (partly because a medication I take blocks its production) and have no pain in the night or morning. My doctor who prescribes the melatonin said I should have a gap of at least two hours between taking prednisone and the melatonin.
Replies to "Melatonin is anti-inflammatory. The cytokine release is due to the lowered amount of cortisol overnight I..."
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I have no opinion about melatonin but sometimes the right answer is that it depends on the circumstances. I used Benadryl (diphenhydramine) for sleep but not so much anymore since I came off Prednisone. I'm given Benadryl and acetaminophen before my Actemra infusion but I don't think I need those medications for my infusion. The combination of Benadryl and acetaminophen helps me sleep.
"Despite these multiple anti-inflammatory mechanisms of melatonin, its role is more complex than simply one as an anti-inflammatory mediator. Prior studies have shown that melatonin’s role differs depending on the stage of inflammation. It appears to have a pro-inflammatory role in early inflammation and an anti-inflammatory role in late inflammation"
https://pmc.ncbi.nlm.nih.gov/articles/PMC7979486/
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I agree with the part about cortisol but it depends on the cytokine. Cortisol normally downregulates pro-inflammatory cytokines and upregulates anti-inflammatory cytokines. Cortisol "regulates" inflammation but that is complicated too.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3186928/