@idlehands I quit Tymlos after 6 weeks due to a parade of side effects, some of which were temporary. The ones that I was not going to accept were the late-day bad leg aches and almost unreal exhaustion...like, barely able to put one foot in front of the other. I know THAT was very depressing. My then-endocrinologist had previously seemed unsurprised/unconcerned about earlier side effects, commenting that those were known side effects, and may well pass. So when the leg pain (6 or7 level) and the exhaustion came along, I knew I could not get used to them and try to wait it out. I had been very busy with a lot of family things that mean a lot to me. I stopped the Tymlos, and in two days began to feel like myself again. Found a new, really awesome endocrinologist who said I was absolutely right to quit the drug. She did persuade me to try the Forteo, even though it is similar to Tymlos, since my spine score was -3.6. I did so, though nervously. I have had a lot fewer issues with it, most of which I can handle, and which may even pass over time. I have been on it almost 3 months. The depression you've had may be related to just feeling so lousy from the drug, in general?? It is exasperating to think of an indefinite period of feeling unable to have your normal life when you can't even be sure that the drugs will really help. This sometimes feels like a do-it-yourself disease with the lack of consistency and clarity . My excellent doctor agrees.