Methotrexate side effects
I was diagnosed with PMR July 2024 and Sjogren's syndrome Dec.2024. I'm down to 5 mg of prednisone a day which seems to be working (except I seem to "flare" when it rains or the barometric pressure changes). My question is about MTX. I take it orally once a week 6 pills 2.5 mg each. The day after I take it I get diarrhea, fatigue and many times nausea as well. The side effects are not as bad as they used to be and I'm wondering if they ever go away or should I ask about a lower dose of MTX.? If I have to put up with the effects for one day, I will. I would just like to know what others experience.
thank you
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I appreciate your comment. I do take folic acid, not sure it does much for the side effects for me.
Thank you for your comments. I had not considered the injection.
Thanks, that is something I want to talk to my doctor about.
Thank you. I do take folic acid and am going to talk to my doctor.
Thank you
I have been prescribed folic acid 1-3 mg daily. I can decide how much I need depending on severity of side effects.
I took MX for about 1 year. Had very few side effects, until I developed pneumonia and ended up in VA hospital for 12 days. The doctors had a difficult time determining what caused my pneumonia. Unfortunately, the doctors don't consult with each other, as my rheumatologist would have told them it was from the MX. Inflammation of the lungs is one of the side effects.
Here is a related discussion to check out too:
- Using methotrexate with PMR: https://connect.mayoclinic.org/discussion/using-methotrexate-with-pmr/
I had a similar experience recently. I was on MX for 18 months with tiredness 1 day a week as the only side effect. Since Jan this year, I ended up in hospital on several occasions with fever, increase in muscle pain, inflammation in spleen and pancreas and eventually severe anemia. All possible side effects of MX but not identified at the time of hospital admissions. No infection and all other possibilities ruled out, so MX was stopped. That was 10 weeks ago, and after a recovery period things have improved significantly. Although still taking too many steroids, bloods and inflammation are back to being normal for someone with PMR.
Thank you