Only because when you read up on SMAD4 it says it's resistant to chemo and radiation. Naliri did not work for me at all while it did for others even if it was just for a few months. My CA19-9 went up by the thousands every 2 weeks. If you read up on each particular mutation and can somehow comprehend the studies on why biochemically they are a mutation and you realize that you keep layering your bodies defense mechanism with these mutations there is a point where chemo and radiation just won't work. It's rare I think, and happens when you have several mutations as I do. I'm not giving up by any means! RMC6236 looks promising and now I'm so irritated wth my accountant/auditor son's advice not to invest in its stock - ha ha!!! Though I have no idea if it's going up!