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Negative Turn in a Long Journey

Pancreatic Cancer | Last Active: Nov 13 6:55am | Replies (106)

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By the way did you know there are certain mutations associated with peritoneal cancer? I repeated my blood biopsy or the Guardant 360 test and a new mutation has been found: SMAD4 which I read is associated with peritoneal cancer and just another mutation along with the others I have KRAS12D, TP53, ATM(VUS) to make fighting this disease that much more difficult as it is resistant to chemo and radiation. Thank goodness I had histotripsy instead of the targeted radiation! I'm trying gem-abraxane once again, but I'm not ignorant to the fact that because of SMAD4, it might not work this time so I am fervently looking for trials that look promising to me that I might qualify for.

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Replies to "By the way did you know there are certain mutations associated with peritoneal cancer? I repeated..."

Can you explain why you feel that targeted radiation would have been a bad choice?