I have had a scope of my pouch, biopsies - don't have results yet, found a polyp but did not remove. Then I had an anorectal manometry procedure to test my sphincter muscles & met with GI the next day. I have a MRI proctogram exam on the 28th, and a PT consult the next day. My GI wants me to try Tremfya, the injection pen since the antibiotics, azathioprine, metamucil & loperamide are not doing much. I don't have pain other than an occasional cramping, no blood, but I cannot for the life of me get my stool to bulk up. Daytimes are usually good, but nights are the issue. I have been on the same med regimen for over 10 years and has worked fine up until about Nov 2023 is when the night leakage began, and was really kind of random. Something that I tink may contribute some is my spouse got a cpap in Nov 2023, and was a horrible snorer, so I would wake up multiple times/night, and if I did I would get up and go to the bathroom. Now I sleep pretty sound, maybe too sound, I don't wake up until it is too late. Anyone have experience with Tremfya? Would love to hear from you.