Have had 38 cycles with Abraxane & Gemczar. CA19-9 rising.

Curious as to your mutation. I read some respond better to chemo then others.

Where did you receive this study from? Interesting as I've had 3 lines of chemotherapy and have active peritoneal cancer and my oncologist is Dr. Seery and this study was never mentioned to me. I wonder which mutations it works on. I was referred to Dr in charge of clinical studies, but there were none for KRAS, TP53, ATM (VUS), or for my new mutation SMAD4.

I found it on-line. A friend had pointed my in the direction of Anktiva and ImmunityBio.

The founder and developer is Dr. Patrick Soon-Schiong. He was a pancreatic surgeon early in his career. Later he developed Abraxane which many of us are familiar with. So he's no fly-by-night.

He's given some recent interviews and so you can find them on Youtube.

My medical team was also unaware of this until last week.

I can’t send the link, but check Nature or NBC new medical tab for study released on 11th. Promising phase 1 trial for vaccine targeting KRAS H12D. Implemented on patients who had surgery. It’s an ELI trial.

Yes, typo. I have KRAS G-2D , TP53. After 4 years thought it was time for new look at mutations. They did a biopsy and unfortunately not enough sample sent for results. I am going to ask for Guardant test again(first time I asked for it was refused). I am glad you did this. After time and chemo, I do believe other mutations occur.

ALL-i will attend the Seema Magowitz conference in Milwaukee this weekend for patients and physicians. many leading professionals in this area will be there. If you have a question you would like asked, pls send my way. It’s an awesome two and a half days with people all over that live and breathe this disease. 💜💜

If you live near there you should come!

Hi
First of all, you're a role model. I've now gone through 20 cycles and 41 treatments of the Abraxane & Gemczar combo over the past 20 months. Nice to hear that you and others have gone longer.
Same situation with the neuropathy (particularly in my feet) gradually increasing.

Couple ideas for you:
1) A new immunotherapy was recently approved for bladder cancer, Anktiva. It was invented by the same guy that invented Abraxane so the credentials are there. It's now been granted Expanded Access Authorization for pancreatic cancer. But you must be in a state of lymphopenia to qualify. Just had the conversation with my doc this week. I'm not there yet. If you are, it might be worth considering.
2) Daraxonrasib (RMC-6236) - don't know much about it but apparently in a Phase 3 study. https://clinicaltrials.gov/study/NCT06625320 Has potential but still might be out a year before approvals.
By the way, are you icing hands and feet while being infused with the Abraxane?
Best wishes.

Bless your heart for all the back and forth flying you do! I'm scared to even get on a plane now for almost 20 years.
My questions would be about the ELI vaccine - is it legit for pancreatic cancer patients abd also if possible to do early release for RMC6236 if the phase 3 results so far are overwhelmingly looking real good now?
Thank you gamaryanne for all you do!

I spoke with Dr. Seery yesterday about the trial requiring lymphopenia. The only result they were looking for was if the trial increased the lymphocytes- that's the only positive results they were receiving.