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Thanks, @dvargo. Yes, I know how flawed the 2000 report was. But my understanding is that estrogen patches (ie. absorbing through skin) can prove a stroke risk. So I don't understand why a cream would be safe.

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Replies to "Thanks, @dvargo. Yes, I know how flawed the 2000 report was. But my understanding is that..."

My understanding is that patches and pellets release hormones directly into the blood stream thereby bypassing the liver making them a safer delivery system.

The case-control study by Renoux and colleagues is the first major analysis to compare transdermal and oral hormone therapy and conclude that, compared with an increased risk of stroke with oral therapy, there was no increased risk with transdermal treatment at a dose of 50 microg or less.
https://pubmed.ncbi.nlm.nih.gov/20670199/