← Return to FOLLOW UP WITH EVISTA AFTER BONE BUILDING DRUGS

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Profile picture for ruthmbm @ruthmbm

Thanks for the information. It was useful in solving the puzzle. It appears that Evista was not really effective in maintaining the small increases you achieved with Prempro.

Unfortunately, so far it appears that nobody on this forum has used Evista after Evenity.

The study you mentioned (Evista after Evenity) was the final study and was conducted in February 2025. There is no mention of any future study to be undertaken using these 2 drugs. See the link below for the full results (including graphs).
https://www.jstage.jst.go.jp/article/jmi/72/1.2/72_124/_pdf/-char/en
Unfortunately, the sample size was only small (only 23 respondents). The study found that Evista maintained bone density for only 6 months after stopping Evenity and then declined to just above the baseline level after 24 months of using Evista after Evenity. (lumbar spine)

Normally I would dismiss a study with such a small sample size. However, these 23 respondents had roughly similar BMD results to the study undertaken by the Evenity manufacturer with very large sample sizes. Therefore, the sample of respondents of 23 maybe be a reasonably representative sample and I should not dismiss the findings.

I have found 2 other studies on use of Evista as a follow-up drug:
After Prolia: Bone density declined to baselevel after 12 months of using Evista (sample size 81)

After Teriparatide: Bone density was maintained for 2 years (sample size 97). NB study was conducted for 2 years.
Note: Broken13 (previous post) took Evista for 5 years after Teriparatide. Evista maintained bone density and only a slight decrease was evident after 5 years. Evista was then followed by another round of Teriparatide. If I could go back in time I would chose this sequence as it avoids the use of Prolia or bisphosphonates as a follow-up drug. Unfortunately, I started Evenity 10 months ago i.e. before the above February 2025 study was started.

Therefore, it appears that the effectiveness of Evista as a follow-up drug depends upon which drug you took before Evista.

My conclusion: Evista maintains bone density after Teriparatide (for 5 years) but fails to maintain BD after Evenity and Prolia.

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Replies to "Thanks for the information. It was useful in solving the puzzle. It appears that Evista was..."

I will look for info on Prempro as a follow up. Hopefully, I'll find something, and the news will be good.

I am due for a bone density in November and will post those results for you. My insurance would not approve Evenity, but did approve Forteo/Teriparatide "because it had proven effective before". I am actually glad it worked out that way, because Evenity is made by same folks as Prolia, which I had reaction to after the first shot. I also appreciate all the research Forteo did prior to release and the follow up I had with them in their initial role out. At now 67, I'm thinking Evista again as follow up and will monitor yearly. I would be willing to do Forteo again in another 5 years if indicated. Although bone cancer in rats was a risk factor, I have not found this anywhere I have read, for humans.