Sue, I'm sorry I haven't replied sooner. I didn't have nausea but did get fatigued every afternoon and it lasted the whole time. If I had time I would take a short nap otherwise I had coffee, even though it's not good, just so I could make it through. I took my shot in the evening before bed. That might help with nausea - you essentially sleep through it. My calcium never went up either. I hope your side effects lessen and that you have a good response to the drug.