Yes, I found that if you are having side effects or have a elevated serum creatinin (impaired kidney functioning) or you are over 80 years old or under 130 pounds, then the dosage can be lowered. I am not 80 yet and I am almost "lean" enough to qualify for a reduced dosage. I am going to ask for a reduced dosage; I don't really feel comfortable on three pretty powerful cardiac medications for the long term. So far, I have been doing well and I don't want to take any more medication than is necessary. Thank you for your input.