Wellbutrin increases levels of dopamine and norepinephrine in the brain, neurotransmitters associated with pleasure, arousal, and motivation. It is usually used as an adjunct to hormonal therapy. It can even lead to an increase in orgasm intensity is some.

It is used off label to treat HSDD hypo active sexual desire disorder.

It is often used to counter effect the low libido side effects of other antidepressants