Apparently when we go off any anabolic, bone building medication (Forteo, Tymlos, Evenity) it is advisable to go on a bisphosphomate or Reclast to “lock-in” the gains. I think this is because our osteoclasts will continue to take away bone at the same accelerated rate for awhile, but our osteoblasts will stop building bone at the accelerated rate immediately. The bisphosphomates stop our bones from remodelling, so if we go on them for one year, the imbalance will be stopped, thereby “locking in” the gains. This is my layman’s way of understanding it, so if anyone has a more technical explanation, please share!!

Prolia works in a different way. It inhibits osteoclasts from removing bone (which helps with density), but doesn’t not stimulate osteoblasts to build more bone. When you go off Prolia, the osteoclasts come out of hidding and start working with a vengeance. This is why some people have fractured vertebrae if they don’t come off of Prolia properly. Again, this is my layman’s explanation:)