My mum had stage IV CTCL and by far for her the itching was the worst. It was so debilitating to quality of life for her she too became depressed and began to disconnect. I think they feel very alone cuz no one can relate to the itching. So many people thought itching was in her head. So very hard to watch your loved one go thru it. The only thing that seem to give her any relief though briefly was the light therapy which we traveled 130 miles 3x week for her to get 30 seconds of treatment. It gave hope. Because of the chemo she could only take few seconds of light therapy because skin too fragile and couldn’t continue until chemo finished. The light therapy was the only type treatment to give her any relief with itching. Hope this might help