@annitab63
I have switched from Cymbalta to duloxetine and my understanding is the main ingredient of the generic should be the same but there may be some differences in fillers. Quality Control issues when manufacturing the drug may be an issue depending on where sourced/manufactured (amount of the actual drug vs fillers and dosage may vary). I do believe some generics are good but you need to check with your pharmacist to see if they have any information about the generic and patients’ issues/reactions and ways to find a generic that works for you. Pharmacists may be able to tell you how other patients transitioned to the generic successfully. They can also work with your doctor to suggest adjusting dosage if needed.