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DiscussionGrade 2 Meningioma Diagnosis: Looking for a place to share my worries
Brain Tumor | Last Active: Jul 27 8:31pm | Replies (17)Comment receiving replies
Replies to "There are many different types of WHO 2 classified meningiomas. Some are more problematic than others,..."
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Did you have NGS (next generation sequencing) performed--the genetic tests of the meningioma itself? A study published in 2022 (Neuro-Oncology 24 (5) ) reclassifies patients based solely on chromosomal deletions. The WHO reclassified people based on 3 specific genetic mutations about 2 years ago.
I find myself with a WHO grade 1 but 5 chromosomal "deletions" on NGS. The Cleveland Clinic group where I had craniotomy, removal of bone where the tumor started, removal of affected dura and a postop neg MRI and PET, has still recommended radiation because of the NGS results.
There is no research on the effects of radiation for people in my situation, and the Clinic has been advising radiation in this situation for only a year. While the numbers in the study are very small, the writers go on record stating that radiation did not appear to modify risk of recurrence for anyone with an 'upgrade" to their WHO grade. Not all of these people, even upgraded to Grade 3 (as I was, tho Grade 2 per the radiation oncologist) had a recurrence during the study time--this says to me that we are not a homogenous group.
I am betting you were a grade 2, gross total resection and would have had a negative PET scan if you had had one performed.
I have elected to have close followup but no radiation.