DUPIXENT (dupilumab)

Yes....we sure want to get those secretions out of our lungs. Thanks, that was my concern knowing what benzonatate does.....the opposite of what we want to happen.
Barbara

I was prescribed Dupixent, a month ago, and have taken two injections. My pulmonologist (who I see at the U. Of Penn Lung Center) encouraged me to try it because his research showed other patients with BE who had high counts of eosinophil, as I do, were having success. I don't feel any different/better after 2 injections (1 every 2 weeks), but was told the drug can take 8 to 12 weeks to take effect. I have a chronic cough and no energy. Let's hope this works.

Yes, let's hope it works.
Please let us know how you are doing every so often on this thread. We will all be interested in what your journey will be with the Dupixent.
My eosinophil count is low. It is my Neutrophils that are about ready to go over the line to high.
I have the chronic need to clear my throat all day long. I do a lot of deep breathing and huff coughing that brings it all up and every so often up comes a mucus plug. At this point my energy level is fine, no fatigue. It's just that there is not enough time in the day to do what one has to do for my BE, Eczema and those daily living activities/housekeeping, cooking, grocery shopping, home daily upkeep and unexpected problems that seem to show up every once in a while. Oh well, all we can do is roll along with the punches!!!!!
Barbara

I so appreciate your post. I’ve been hoping to see something about the Dupixent. A friend mentioned that a relative of hers had Mac Absesses and that her doctor had prescribed the Dupixent for eczema and out of the blue, her Mac Absesses appeared to be gone. It related to the inflammation and the symptoms from that. Is there anything that anyone has seen in the research/NIH that they could post a link. Thanks ever so much. I so appreciate all of you.

I hadn't heard anything about cromolyn in many years (ret. nurse) and this is the second mention this month. It's used occasionally as a mast cell stabilizer in a small subset of patients with chronic urticaria.
No need to reply...just thought it an interesting coincidence/tidbit.

Took brief look at pubmed and found this case report that showed decreased mucus plugging.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11233258/

I just did a quick look. Enough to see the images. What a difference. GOOD RESEARCING pacathy!!!!
What would we do without the ability to communicate with each other on Mayo Clinic Connect. Mayo and people like you are such a big help. Thanks. Wonder if another thread should be started such as "Dupixent, a success story." If you think it a good idea, would you have time to begin such a thread?????
Barbara

I'm glad it was helpful and agree that it's a hopeful case. It's also hopeful, I think, that it's working for other conditions with inflammation. However, I think it's too early to start a new thread and get people's hopes up. It's a case report that may inspire the company to do a trial and from the thread, it sounds like there are cases that show promise. I briefly looked at Sanofi's site and clinical trials.gov site and didn't see a trial including bronchiectasis. Remember, it takes many cases to be sure it's the medication and not something else (such as more airway clearance, a supplement she started, etc) cases the change.
Feel free to share if you want, but I feel it's early.