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Tapering off quetiapine

Mental Health | Last Active: Apr 3, 2024 | Replies (41)

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Hi. I'm hoping to get some help or reassurance that what I'm experiencing is fairly common and that it will improve with time. I was prescribed Seroquel/Quetiapine for insomnia (IR, regular, not XR) to take nightly or as needed, 25 or 50mgs, by a nurse practitioner. I took it most nights anywhere between 12.5 and 50 mg doses from October 2024 until June 2025, about a total of 220 x25mg pills over about 9 months.

It helped insomnia tremendously with no other side effects (that I could notice). Around June 29, 2025 I stopped cold turkey as I was becoming worried about potential side effects of long term use. About 11 days after stopping I suddenly started feeling dizzy. Not a regular dizzy, more like a persistent and consistent "stoned in a bad way" dizzy, feeling really drugged, that isn't going away, it is now day 13 of feeling this way. Secondary (not as persistent, consistent, or bothersome) sensations are a weird internal body buzz and a strange bitter taste in my mouth. No other symptoms, blood pressure and temperature are fine, as are nutrition and hydration, no other meds (other than Reactine for allergies, and supplements - nothing new in the last few months however), nothing new ingested. I have been under a tremendous amount of stress and anxiety for years, plus perimenopause, but I have never experienced anything like this persistent "stoned" feeling. It feels too coincidental to stopping Seroquel, though I never thought that quitting it after only on it 9ish months at low dose would cause something this horrendous. The NP who prescribed it said that it is very safe, non addictive, can just use it as needed for sleep or discontinue.

Is there anyone out there who has experienced something similar? Please put my mind at ease and tell me for how long, and what helped you, this is terrifying, and I can't help but spiral into worrying about things like MS or brain tumours or some other scary causes, even though the onset of this awful "stoned" feeling came shortly after discontinuing Seroquel. Thank you.

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Replies to "Hi. I'm hoping to get some help or reassurance that what I'm experiencing is fairly common..."

welcome to Mayo connect, read your post and like bewildered posted never heard of using that for sleep only help i can be is letting you know some drugs depending on the person and what they are already taking as to medications that going cold turkey on anything without doctor approval can be dangerous and possible side effects. especially after being on them for months. you have to wean yourself off just about everything today. good luck in your search. keep us posted on your status please. i would be asking my doctor first sign of symptoms. have a blessed day.

I was given a dose of Seroquel for severe insomnia that came on rapidly.
1) I twitched badly all night long and refused to take it ever again.
2) I figured out my insomnia cause which doctors didn’t even think of - it was post a 10 hr surgery, for which I had been in horrible pain for months and basically I felt so good that I went off my postop narcotics (which I’d also needed preop) too fast and was in withdrawal.

Hi there, the brain chances permanently after a long period (1 year) of low dose of seroquel 50mg, even after stoping to take it. It causes a huge widrawal from work and social life because it strongly damages the brain while it's making you sleep. Causes cognition impairment(memory, thinking reasoning planning), difficulty om acomplishing tasks and being satisfied with it. Damages ability to process emotions, slows all your reactions. Nervous systems slows dramatically, loss of excitement, passion, love. It burns too many neurons which are essential. Your intestines become more constipated and slower. You body looses mucles and coordination because it makes you do less of everything. It causes apathy and a strong isolation from your family, friends and love partners. The result is losing your job, your love partner and steping away from friends. The effort one makes to regain the life as it was before taking seroquel is huge to achieve very low results, only to realise that you are just strugling and can't be yourself anymore. This medicin should never be prescribed for insomnia, depression or anxiety in low doses. Seroquel is basically slowly killing anyone who takes it.

Between meds for type 2 diabetes and breast cancer prevention, for anxiety, depression and insomnia, I use a prescribed device called Alpha Stim. Its not perfect but better than adding more meds to my cocktail. For sleep, I also take magnesium and drink chamomile tea and use a CPAP.

Worst drug I have ever been on. I've been on it for 10:15 years 100 mg. It was help me sleep that's what I was prescribed it for for a few years but it also made me lethargic foggy depressed just not me just not in my right mind. So I've been trying to get off it for the last 8 years and kept get going back on it because I couldn't sleep. But in the last year and a half it is made it is worse I can't get out of bed in the morning I'm so groggy and so depressed. So I said I'm going to do this. I wean myself from 100 mg to 75 to 50 to 25 8 weeks. I am going through withdrawal symptoms I am sleeping two and a half hours a night psychiatrist is not taking me seriously. I just heard that it is a street drug now called Susie q that people abuse just like heroin another street drug they call Seroquel is baby q. I don't know when the withdrawals will go away if they do it also says it damages your brain and it takes three to four years off your life. Also causes dementia and brain damage. All I wanted to do was sleep when I was having a hard time 10 to 15 years ago they never told me about this. I don't know if I've helped you but it's the worst thing that ever happened to me. And I'm still going through it I will not ever go back on it again. And I am not living my life I'm staying in bed until this goes away Thank God I'm retired. Sad thing is is that I am not socializing and not even seeing my children cuz I feel so bad. It's like coming off opiates

Are you able to sleep are you able to live life? Without it? Cuz I can't and I've been 7 days off it. Stay off at I advise you. Look it up look it up on the Mayo clinic look it up on YouTube there's people that actually have taken it and told them us what it did to them there's some permanent damage it can do. Even Google has some good points. They're actually selling it on the street now baby q

Most anti depressants and will have bad withdrawal side effects. You should never stop them cold turkey without medical assistance. You need to work with your doctor and set up a withdrawal plan. It can take a long time to do it safely and with as few side effects as possible. Effexor is very hard to get off of, and I took a good 9 months to slowly wean off of it. By the end, I was taking just a crumb of a pill. This has to be done very slowly, or you will be in bad shape for a long time.

You never cold turkey stop Seroquel. I weaned myself from 100 mg to zero after 8 weeks. Then the first few nights even taking lunesta which is a sleep aid I didn't sleep for 3 days. Then I'd get two and a half 3 4 hours of sleep the first week. The second week my doctor added Prazosin. It's a BP medication, but it helps the core. Anyways it takes weeks, sometimes months for your nervous system to calm down it's saying hey where's the Seroquel I'm missing the Seroquel? It suppressed your emotions and your nervous system. I took it for 10 to 15 years and tried to wean myself off it for the last eight or nine and couldn't do it. Because I couldn't sleep. But I started feeling so groggy and so depressed on wake up the last 2 years I had to bite the bullet and wean myself off. It was hell. I'm still not sleeping a full night's sleep but I'm getting 7 hours here and there waking up to use the bathroom but normally fall back asleep. Didn't you talk to your doctor about this first? Are you sleeping? I feel a little flat not stoned myself. But I think it'll be better in time. Are you taking any sleep aids?