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Tapering off quetiapine

Mental Health | Last Active: Apr 3, 2024 | Replies (41)

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Hi. I'm hoping to get some help or reassurance that what I'm experiencing is fairly common and that it will improve with time. I was prescribed Seroquel/Quetiapine for insomnia (IR, regular, not XR) to take nightly or as needed, 25 or 50mgs, by a nurse practitioner. I took it most nights anywhere between 12.5 and 50 mg doses from October 2024 until June 2025, about a total of 220 x25mg pills over about 9 months.

It helped insomnia tremendously with no other side effects (that I could notice). Around June 29, 2025 I stopped cold turkey as I was becoming worried about potential side effects of long term use. About 11 days after stopping I suddenly started feeling dizzy. Not a regular dizzy, more like a persistent and consistent "stoned in a bad way" dizzy, feeling really drugged, that isn't going away, it is now day 13 of feeling this way. Secondary (not as persistent, consistent, or bothersome) sensations are a weird internal body buzz and a strange bitter taste in my mouth. No other symptoms, blood pressure and temperature are fine, as are nutrition and hydration, no other meds (other than Reactine for allergies, and supplements - nothing new in the last few months however), nothing new ingested. I have been under a tremendous amount of stress and anxiety for years, plus perimenopause, but I have never experienced anything like this persistent "stoned" feeling. It feels too coincidental to stopping Seroquel, though I never thought that quitting it after only on it 9ish months at low dose would cause something this horrendous. The NP who prescribed it said that it is very safe, non addictive, can just use it as needed for sleep or discontinue.

Is there anyone out there who has experienced something similar? Please put my mind at ease and tell me for how long, and what helped you, this is terrifying, and I can't help but spiral into worrying about things like MS or brain tumours or some other scary causes, even though the onset of this awful "stoned" feeling came shortly after discontinuing Seroquel. Thank you.

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Replies to "Hi. I'm hoping to get some help or reassurance that what I'm experiencing is fairly common..."

Welcome to group was me. Getting off medication of any type cold turkey has effects on you. I've been getting lowered on my meds, hoping to get off them all at some point .came down to quickly and ended up having to relax and start over by increasing one of the meds i was trying too get off of. Dizzy spells return, but getting better as the days pass. Everyone is different, what works for one might not for another. But be patient and keep asking questions. Be safe

Don't know if I helped any, but best of luck getting your answers.

Welcome to the group,

Like a dad, stop with the what if, worrying. Life is two short anyway. Try to make some one smile or flirt a little, maybe help them with a issue they are trying to solve. Ill be 69 this year and shooting for many more years to come. Just can't drive for another year no worry, I got this and so do you. Enjoy being yourself and alive to help.

My mom was on Seroquel for a while, and I did a ton of research and talked to her doctors and local pharmacists about it.
From what you've described, it sounds like withdrawal symptoms. Even though some doctors might say it isn't addictive, the body can become dependent on it, even in low doses. When you stop taking it, your brain has to re-regulate itself, and that can cause a variety of strange symptoms.

Everyone reacts differently, but it is very common for symptoms to show up a week or two after quitting. The "stoned" feeling, the internal body buzz, even the bitter taste could be all signs of withdrawal.

As for how long it lasts, that's really tough to say. For some people, it's a few weeks, for others, it can be a couple of months. The good news is that it almost always gets better with time.

Just be patient and try to manage anxiety. I know it is easier said than done, but the stress can make the symptoms feel worse. If it bothers you and you can not wait for it to go away, you can always talk to a different doctor, who has more experience with this kind of thing.
Hope I helped a little bit, let me know when you are better.

Hi albv9,

I've been taking Seroquel for the same reason, as a sleep aid and secondly as a "mood stabilizer" for over 20 years. I'm 70 y/o now and am still taking it.

I'm not a Dr, but I haven't experienced any lt affects from the drug and my Dr still prescribes it.

I suggest talking with your Dr. Maybe it's not necessary to stop.

All the best to you.

Joe

This is happening to me just over two weeks now,was on and off it every week for awhile,now I feel noty self,funny taste in mouth,buzzing ears,dizzy well funny kind off dizzy,my circulation seems funny as well,when put and about I feel strange in the head,kinda like being locked in Ur own head

My Dr. wants me to go from 100mg. Seroquel to 75 for hand tremor and dizziness. I don't want withdraw crap. Would it be easier to taper down 100mg gabapentin to 50 mg that only helps me sleep?

Quetiapine has more side effects than I read about,
I was taking 50 mg before bed,
I am in the process to discontinue and reading about

I have never heard of anyone taking Seroquel, an anti-psychotic, for insomnia. I think there are probably several better medications for help with sleeping, with fewer side effects. I wish you success in your journey.