1. < Prostate Cancer
Profile picture for vcash

Can anyone share their experience with Pluvicto?

Posted by vcash @vcash, Apr 22, 2024

My 85 year old dad has prostate cancer that has metastasized to his bones. Zytiga is no longer effective. He is considering Pluvicto. I would appreciate input from those who have used Pluvicto.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for scalecraft
scalecraft | @scalecraft | Jul 2 3:23pm

Trip out, lunch with a good friend, all went well, still a bit of dizziness, fatigue seems to be more manageable.
Ain't this FUN?

REPLY
Profile picture for mary1915
mary1915 | @mary1915 | Jul 3 8:05am
In reply to @eugenelapietra1 "76 years old in the same boat your dads in. Treatment #1 not bad at all,..." + (show)
Profile picture for eugenelapietra1 @eugenelapietra1

76 years old in the same boat your dads in. Treatment #1 not bad at all, treatment #2 a little rough, Treatment #3 a total nightmare, Treatment #5 I didn't think I was going to survive. I don"t have a choice I'll take Treatment #5 and pray..........The rub is , everyone may have a different experience so I suggest gathering more testimonials . Pluvicto with all its unknowns is still the only game in town. If you decide to go through with the treatments you can contact me and I'll share with you some tips on how to make your dads trip easier. God Bless ,Gene

Jump to this post

Thank for sharing.
My husband(75 years old) just started his 1st treatment of Pluvicto. He has lots of pain in his lower back and some leg pains. Has issues walking. His next 2nd treatment is in August. What should he expect on the 2nd round?

REPLY
1 reply
Profile picture for kjacko
kjacko | @kjacko | Jul 3 9:38am

My friend just ended his Pluvicto treatments and said it’s the best he’s felt in four years. Hope this helps and good luck.

REPLY
1 reply
Profile picture for jeff Marchi
jeff Marchi | @jeffmarc | Jul 3 10:36am
In reply to @mary1915 "Thank for sharing. My husband(75 years old) just started his 1st treatment of Pluvicto. He has..." + (show)
Profile picture for mary1915 @mary1915

Thank for sharing.
My husband(75 years old) just started his 1st treatment of Pluvicto. He has lots of pain in his lower back and some leg pains. Has issues walking. His next 2nd treatment is in August. What should he expect on the 2nd round?

Jump to this post

Usually, the side effects are similar for the first three treatments. Some people can’t get past the first visit without serious side effects.

He will probably feel Back to normal a Couple of weeks before his August treatment

REPLY
Profile picture for mary1915
mary1915 | @mary1915 | Jul 3 12:21pm
In reply to @kjacko "My friend just ended his Pluvicto treatments and said it’s the best he’s felt in four..." + (show)
Profile picture for kjacko @kjacko

My friend just ended his Pluvicto treatments and said it’s the best he’s felt in four years. Hope this helps and good luck.

Jump to this post

Thank you for the encouragement. I pray it works for my husband.

REPLY
1 reply
Profile picture for kjacko
kjacko | @kjacko | Jul 3 5:28pm
In reply to @mary1915 "Thank you for the encouragement. I pray it works for my husband." + (show)
Profile picture for mary1915 @mary1915

Thank you for the encouragement. I pray it works for my husband.

Jump to this post

Thought and prayers🙏

REPLY
Profile picture for jay0013
jay0013 | @jay0013 | Jul 20 12:15pm

Has anyone finished all 6 treatments with Pluvicto? If so would you please share the outcome. How long has it been since completing the treatment?
Thank you for your reply
Jay

REPLY
2 replies
Profile picture for jeff Marchi
jeff Marchi | @jeffmarc | Jul 20 1:12pm
In reply to @jay0013 "Has anyone finished all 6 treatments with Pluvicto? If so would you please share the outcome...." + (show)
Profile picture for jay0013 @jay0013

Has anyone finished all 6 treatments with Pluvicto? If so would you please share the outcome. How long has it been since completing the treatment?
Thank you for your reply
Jay

Jump to this post

I know a few people that have completed it and results vary. Some had the cancer stay away for a well over a year Other people have had it come back.

It is a known fact that 1/3 of the people get really good results 1/3 of the people get OK results and 1/3 of the people get no results at all.

One thing you should be aware of are Pluvicto genetic issues
RB1, PTen, TP53 are Pluvicto resistant
ATM & BRCA work better with Pluvicto

If you got a hereditary, genetic test You would know if you have any of these. Has it been offered to you by a doctor? You can get it done free with the below link, if you live in the United States. Do not check the box that you want your doctor involved or they won’t send you the kit until they get in contact with your doctor. It takes about three weeks to get the results and then a genetic counselor will call you.
`
Prostatecancerpromise.org

You get a somatic Genetic test using blood or tissue to find out whether or not you have one of those genetic issues now. Things do change, and some people do get these genetic anomalies. Ask your doctor about this.

REPLY
Profile picture for melcanada
melcanada | @melcanada | Jul 21 6:16am
In reply to @djnavigator25 "I am starting Pluvicto soon. I chuckled about the Nuke subs. That was my experience, too,..." + (show)
Profile picture for djnavigator25 @djnavigator25

I am starting Pluvicto soon. I chuckled about the Nuke subs. That was my experience, too, about 50 years ago. All the best!

Jump to this post

What is your experience so far ?

REPLY
Profile picture for jay0013
jay0013 | @jay0013 | Jul 29 8:07pm
In reply to @jim401 "Pluvicto was started as my PSA abruptly increased from a low of 8 after doxetaxel treatment..." + (show)
Profile picture for jim401 @jim401

Pluvicto was started as my PSA abruptly increased from a low of 8 after doxetaxel treatment to 17 a few months later. By the time Pluvicto was started the PSA was 198.
After the first infusion, the PSA dropped to 100. After the second infusion, up again to 120. After the third infusion, the PSA was 364 - obviously a treatment failure. Options now are essentially nonexistent. I am unwilling to accept the debilitating side effects of a repeat doxetaxel ( or other chemo agent) for minimal short term benefit.

Jump to this post

I've been looking into immunology which has been improving good results for mCRPC. Might be something that will work for you.

REPLY
View MoreView Less
Please sign in or register to post a reply.