I personally have not tried LDN. Now that my EBV IgM is negative, I don't see a point in me pursuing it. I have, however, heard from folks with EBV who say it has helped them. I think it depends on what is really going on in the immune system and if there is a lot of inflammation. This article explains how it works and possible side effects for those who are interested. https://kresserinstitute.com/low-dose-naltrexone-promising-drug-hard-treat-conditions/