Calming the gut brain

Posted by ajh5285 @ajh5285, Jun 4, 2023

This may seem like a humorous question, but I'm asking in all seriousness, since I have long-standing chronic stressors in my life over and above my current health problems. Given my current situation, those chronic stressors are not susceptible to easy fixes. Hence my interest in the possibility of other strategies.
My major medical situation is that I was diagnosed (then age 73) last year about the end of summer with inoperable adenocarcinoma of the pancreas; probably already with lung mets.
At my most recent medical evaluation 2 days ago, my oncologist was not satisfied with the response of my tumor to gemcitabine - abraxane, so has decided to switch me to a different 2-drug therapy, the details of which I am fuzzy on at this point, other than it involves one oral med and one to be administered via an infusion pump over 46 hours. This new therapy is scheduled to start around 10 days from now.
In the meantime I am feeling abandoned to my own devices - "abandoned" being the key word. Rationally I realize that is not so. But I'm finding that my emotions (anxiety leads the crowd) are not so easily ratcheted down. Hence the question that heads this post.
Additional recent observations leading to my question are:
Learning to switch off negative thought trains, even temporarily, has helped some, particularly when I am preparing to go to sleep for the night.
Unexpectedly, I have discovered that I am much more comfortable physically when I have congenial visitors or can experience some rare tranquility in my life.

This has somehow led me to remember the evidence that we have a larger "brain" in our gut than the one in our heads.

Does anyone have any experience to share that indicates what approaches have worked or not worked?
I'm prejudiced against pharmaceutical approaches since my professional experience in health care indicates that one drug prescription frequently leads to the necessity of prescribing another drug to treat the side effects of the first, which then may need another prescription drug to prevent the new side effects.

On the other hand is there even such a "thing" as talk therapy for the gut-brain? Or anything else that has proven effective?

Interested in more discussions like this? Go to the Pancreatic Cancer Support Group.

Profile picture for wishingonastar @wishingonastar

Thank you so much for responding Janell, and for sending those links. How kind of you to be a volunteer mentor. Yes, this has been a long journey to get this diagnosis. Mayo was fantastic and we will follow their protocol. I am guessing there is going to be more research on the mind-gut disorder. I hope we hear from others on their journeys as well.

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I’m not sure what DGIB is, but Yes, I did some deep diving into the brain/gut connection (of course with Mayo which has been my go -to for many years through several severe health issues with my husband and myself as well). And I did find there is definitely that connection after presenting my thoughts and information to my gastroenterologist NP. I also work with a holistic practitioner who has been talking of the great importance of the gut biome to me for years! , I was gene -tested and found that Pristiq works best for my Makeup and body type. That may be your first step. Good luck! And thank you Janelle for the information, too!

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Profile picture for wishingonastar @wishingonastar

Anyone diagnosed with this find any relief? Mayo Clinic recommending biofeedback PT, GI psychologist, Ozempic type medications. Major symptoms chronic long term diarrhea initially triggered by adverse reaction to Zoloft. Thank you.

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Thank you so much for your comments and good wishes. I will check out Pristiq, and all the best to you.

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Profile picture for wishingonastar @wishingonastar

Thank you so much for your comments and good wishes. I will check out Pristiq, and all the best to you.

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You should request gene-testing from your doctor before getting a prescription for Pristiq 😊

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Profile picture for wishingonastar @wishingonastar

Anyone diagnosed with this find any relief? Mayo Clinic recommending biofeedback PT, GI psychologist, Ozempic type medications. Major symptoms chronic long term diarrhea initially triggered by adverse reaction to Zoloft. Thank you.

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Has anyone been diagnosed? I went to Mayo and this is the only thing they could come up with. I have been sick for years and got no answers. I guess it’s kind of a new thing and they are still learning about it.

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Profile picture for hansenshorses @hansenshorses

Has anyone been diagnosed? I went to Mayo and this is the only thing they could come up with. I have been sick for years and got no answers. I guess it’s kind of a new thing and they are still learning about it.

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I have not been diagnosed with this and appt with a GI doctor is November but I suspect I do. I did research. I take an anti epileptic drug . Had gall bladder removed in October 2014. The so called good bacteria in my GI tract effected by this. I have constipation gas etc. My neurologist reduced the dose of my anti epileptic drug. I added a probiotic supplement earlier this month. Been working on dietary changes as well since January. I am finally better. I do not know to put in my comments the specific journal articles where I find this but they are medical journals. The gut brain axis is linked to depression anxiety and other neurological issues.

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Profile picture for frygirl777 @frygirl777

Hi! I’m glad the CBD oil is helping you sleep. Is there a particular type you take to help with sleep? I heard that Indica RSO (Rick Simpson oil) is supposed to be good. I struggle with sleep now due to the steroids they have me on for my horrible chemo induced nausea. I need more rest & I am not getting near enough.

Thank you!

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Have you looked into GABA. Relaxes my mind.

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Tai Chi can help with giving you a better way to breathe and concentrate. There are some resources online to try without committing to a group. John Monroe has some good facebook posts.

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Profile picture for hansenshorses @hansenshorses

Has anyone been diagnosed? I went to Mayo and this is the only thing they could come up with. I have been sick for years and got no answers. I guess it’s kind of a new thing and they are still learning about it.

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Hi @hansenshorses. Being sick for so long is difficult. I have been struggling for a while as well, I feel your pain.

Are you saying Mayo Clinic, I assume GI gave you a diagnosis of “Disorder of Gut-Brain interaction“, same as @wishingonastar?

Are you comfortable sharing more about what brought you to Mayo and what they recommended? How is this impacting your day-to-day currently?

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Profile picture for kb2014 @kb2014

I have not been diagnosed with this and appt with a GI doctor is November but I suspect I do. I did research. I take an anti epileptic drug . Had gall bladder removed in October 2014. The so called good bacteria in my GI tract effected by this. I have constipation gas etc. My neurologist reduced the dose of my anti epileptic drug. I added a probiotic supplement earlier this month. Been working on dietary changes as well since January. I am finally better. I do not know to put in my comments the specific journal articles where I find this but they are medical journals. The gut brain axis is linked to depression anxiety and other neurological issues.

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@kb2014, it sounds like you have been dealing with symptoms for a long time and are making progress. A GI appointment sounds like a good idea.

You mention going to a neurologist and making medication/supplement as well as diet changes that are helping.

What are the symptoms you are dealing with? How are deciding what changes to make?

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Profile picture for wishingonastar @wishingonastar

Anyone here been diagnosed with Disorder of Gut-Brain interaction?Chronic diarrhea triggered by high dose of Zoloft, that never stopped. Mayo Clinic recommending Ozempic type medicine, GI psychologist and GI biofeedback therapy. Anyone try?

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Gas constipation bloating. My anti epilepsy drug lamotrigine can cause this. Dose was reduced 50 percent. Remained seizure free. This was 6 months ago. I added a probiotic supplement. I had been improving till today. I think I made the following mistakes. Too much bread. Then too many servings of beans to relieve the constipation. I take docusate and generic Metamucil. 2 days ago another mistake. Diet pepsi. I also think onions are a no no. Lots of fluids. Water with water flavor packets. AEDs can cause gut dysbiosis. Had cholesytectomy fall 2014 so the bile pouring into my intestines causes gut dysbiosis. I do not take much prescription meds. Don't want to add more. Also. I do better with home made bread.

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