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Profile picture for 1pearl @1pearl

Hi Lori,

Thank you for your informative reply. Please explain what you meant and how it could have been done by writing you wished you had a bone marrow biopsy earlier than you did as maybe you would have had an opportunity to to reduce your progression to AML How does one reduce there progression to that and any MPN? I need to learn how.

Thanks and hope your day is going well.

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Replies to "Hi Lori, Thank you for your informative reply. Please explain what you meant and how it..."

Hi @1pearl, There are a number of different blood conditions and cancers with subsets to each. In your case you were diagnosied with ET/MF which are types of MPNs (myeloproliferative neoplasms).
I had AML,which is an acute form of a myeloid leukemia. MDS, (myelodisplastic syndrome) is a type of blood cancer. Some forms of MDS can mutate and progress quickly to AML. Knowing what I know now, I suspect I may have had MDS which accelerated to AML. But by the time I was diagnosed, my blast cell count (cancer cells) composed 85% of my blood, requiring months of aggressive chemo to get me to remission so that I could have a bone marrow transplant. Had my complacent PCP followed up with original bloodwork the year before (I was not aware) or referred me out to a H/O, I might have known about the MDS and had a pre-emptive transplant. I would have insisted on more testing and a bone arrow biopsy. But that’s water over the dam now. 😉

For MPNs, several options for treatments are listed in informational articles. Some may help slow the progression, depending on the type and risk factors. Here are a couple of articles from reliable sources. Not sure if I’d posted them for you before or not. But interesting reading.
~Mayo Clinic: https://www.mayoclinic.org/diseases-conditions/myelofibrosis/symptoms-causes/syc-20355057

~Health line:
https://www.healthline.com/health/cancer/myeloproliferative-disorders
You may not need any intervention for a long time, if any. I know you’re super active, you eat healthy and exercise. Plus you have a wonderfully positive attitude. All of these make such a huge impact on our lives. So keep up with regular labs but don’t let any of this interfer with your joy of life!