Anyone in Clinical trial for MEK Inhibitor IMM-1-104. NCT05585320?

Posted by sandyk62 @sandyk62, May 9 9:19am

Has anyone participated or currently participating in this clinical trial? Everything I have found looks promising. I’m considering participating in this study. The good thing is you get chemo and the trial pill. This is not a random or blind study. Any information anyone can provide would be greatly appreciated.
Thank you,

Interested in more discussions like this? Go to the Pancreatic Cancer Support Group.

marienewland | @mnewland99 | Jun 29 8:23am

In reply to @gamaryanne "@mnewland99 Have the RM drugs been a consideration for you? The pan KRAS 6236 drug?" + (show)

I did look into it 6236 through my UCLA oncologist I used to go through and was told I don't qualify because I've had 2 many lines of chemotherapy. How the city of Hope oncologist was going to try and get me in the randomized study is a wonder to both Hoag and UCLA. I did tell UCLA I was positive for CLD18.2 protein in gastric area and they a phase 1 study so new I don't see anything about it online yet, but I do have appt with oncologist July 21. I also have appt to look at Histotripsy for liver July 8. I did take the steroid pills following my 2nd session of Naliri and it made a huge difference for me; no real side effects so far with the exception of a little weakness. Also, when asked what I needed from friends, I asked for a scapular (something Catholics occasionally wear), and so I'm wearing it. Anyways, I'll be walking today with my walking buddy so incredible vast difference when compared 2 weeks ago. How are you doing with Naliri and your antigen? Is it working for you?

jymurawski | @jymurawski | Jul 2 4:33am

My pancreatic cancer metastasized to my peritoneal lining. I just had my 7th round of chemo which lowered my CA 19-9 but it is starting to rise again. I don’t have any idea how to start looking for a clinical trial. Rush Hospital where I received treatment does not currently have any. How do I start?

marienewland | @mnewland99 | Jul 2 12:14pm

In reply to @jymurawski "My pancreatic cancer metastasized to my peritoneal lining. I just had my 7th round of chemo..." + (show)

https://clinicaltrials.gov/
You can start here or contact PanCan.org and fill out a form and they will help you. Some oncologists heavily in research, may also guide to research. Yo can search on keywords in the above link, pancreatic cancer. Best wishes in finding a winning trial.also, whatever facility you are at, you can search clinical trials on that website and they may also help you.

marienewland | @mnewland99 | Jul 2 12:16pm

In reply to @jymurawski "My pancreatic cancer metastasized to my peritoneal lining. I just had my 7th round of chemo..." + (show)

Also, if you have had a previous biopsy, test your tissue for the CLD18.2 protein that often occurs in gastric cancer. I tested positive for it, and that's my main area of problem, also.

burlslinda | @burlslinda | Jul 2 7:25pm

In reply to @stageivsurvivor "Are you aware that histotripsy is already available here in the US at multiple locations for..." + (show)

I do appreciate your information and I will dig in further and contact each of those places, but I looked up each of these and find nothing in the US for histotripsy for pancreatic cancer. In fact, it seems the first trials for liver histotripsy were also in Spain. I'm sure it will get here, but we need help now.

jymurawski | @jymurawski | Jul 3 8:26pm

Thank you for your advice. Truly appreciate your help.

sandyk62 | @sandyk62 | Jul 13 8:01am

In reply to @mnewland99 "I did look into it 6236 through my UCLA oncologist I used to go through and..." + (show)

Did you get accepted to do the histotripsy ?

sandyk62 | @sandyk62 | Jul 13 8:08am

In reply to @burlslinda "Wishing you the best as you start the trial. Some of the days are very long,..." + (show)

Just following up, how are things going with the trial? Any side effects? Have you got your scan results back yet? I hope that this trial is a game changer for you!!
I started the trial last week. No real side effects except some fatigue. May God put a healing hand over all of us that are fighting this disease.

marienewland | @mnewland99 | Jul 13 11:36am

In reply to @sandyk62 "Did you get accepted to do the histotripsy ?" + (show)

Hi there @sandyk62
Yes, I had a contrast ultrasound and it showed 2 liver lesions at 3cm each so they were seen "amenable to histotripsy." My procedure is scheduled for end of July; a 4hr procedure under anesthesia so I'm trying to take care of myself in anticipation of the procedure. I'll post about it once it's completed.