Hi just a quick update on my treatment, I was diagnosed with two mutt Jak2 and Calr , apparently to have one is ok but two is very unusual...my platelets were over 700 and haemoglobin dropped to 8 mg. Fatigue was the worst aspect. I was on Hydrea for some months with no real affect, I also had 3 transfusions to help the anaemia. Subsequently I've been taken off the Hydrea and now inject weekly with interferon 150 ml and once every three weeks with Aranesp 300 ml, the platelets have started to come down and the haemoglobin has come up from 8 to 10.4. it's still early days and the chronic fatigue is still there but at least the bone marrow is functioning a little better...hope this is of help or of interest..my final diagnosis was MPN ET