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Husband’s low psa, aggressive Gleason 8
Prostate Cancer | Last Active: Jul 27 2:32pm | Replies (35)Comment receiving replies
Unlike other injectable ADTs, Firmagon lowers testosterone levels quickly, which should correspondingly drop PSA levels quickly.
Clinical studies have shown that Firmagon reduces PSA levels by about 64% after 2 weeks, 85% after 1 month, and 95% after 3 months,
> At each of his PSA readings, what were his testosterone levels?
> From his MRI and biopsy reports, was there any mention of cribriform pattern or intraductal carcinoma?
In my case —> For my localized, 4+3=7, PSA of 7.976, at 65y I had 28 sessions of proton radiation + 6 months of Eligard.
> my 1st Eligard injection was on 14 April 2021
> started 28 proton radiation treatments on 19 April 2021
> by 26 May 2021, my PSA was down to 0.224
> ended proton radiation treatments on 28 May 2021
> by 9 July 2021 (at the time of my 2nd & final Eligard injection), my PSA was down to 0.008, and remained there until the Eligard began to leave my system in January 2022.
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"Unlike other injectable ADTs, Firmagon lowers testosterone levels quickly, which should correspondingly drop PSA levels quickly."
Exactly. That's why they put me on Firmagon initially in 2021: I was in severe medical crisis (including paraplegia from rapid spinal compression) and couldn't risk the initial testosterone surge that comes with Lupron.
Now, I'd be able to go on Orgovyx instead, which works the same way as Firmagon but without the acute side-effects around each monthly injection (a few days of flu-like symptoms, swelling around the injection sites, etc), but Pfizer hadn't obtained Health Canada approval for Orgovyx yet in 2021.